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- ***************************
- * Galactokinase signature *
- ***************************
-
- Galactokinase (EC 2.7.1.6) [1] catalyzes the first reaction of galactose
- metabolism, the conversion of galactose to galactose 1-phosphate. There
- are three well conserved regions in the sequence of eukaryotic and prokaryotic
- galactokinase. As a signature pattern we have selected the best conserved of
- these regions, which is located in the N-terminal section of galactokinase.
-
- In yeast the GAL3 protein [2] is required for rapid induction of the galactose
- system. The exact function of GAL3 is not known, but it may be involved in the
- production of a true inducer or coinducer molecule. The sequence of GAL3 is
- closely related to that of galactokinases.
-
- -Consensus pattern: G-R-x-N-[LIV]-I-G-E-H-x-D-Y
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Note: see also the section describing the pattern for the GHMP kinases ATP-
- binding domain.
-
- -Last update: October 1993 / Pattern and text revised.
-
- [ 1] Debouck C., Riccio A., Schumperli D., McKenney K., Jeffers J., Hughes C.,
- Rosenberg M., Heusterspreute M., Brunel F., Davison J.
- Nucleic Acids Res. 13:1841-1853(1985).
- [ 2] Bajwa W., Torchia T.E., Hopper J.E.
- Mol. Cell. Biol. 8:3439-3447(1988).
-